The US will be heavily focussed on its domestic agenda and the pandemic will dominate American politics for the first year of the Biden administration.
That exceptionalist narrative then shifts in 1941 after entry into World War II. It takes a radical turn: "if the United States cannot change the world through example, then it will have to do so through engagement and activism". The country then effectively becomes a crusader, which sets off a long era of liberal internationalism that endures through the presidency of Barack Obama.
What I think we are now witnessing is a swing of the pendulum back, not to isolationism, but to something that would constitute a middle ground between these two long eras of American foreign policy.